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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
16/06/2017 |
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Data da última atualização: |
16/06/2017 |
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Autoria: |
LOBLEY, G. E.; CONNELL, A.; BUCHAN, V.; SKENE, P. A.; FLETCHER, J. M. |
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Título: |
Administration of testosterone to wether lambs: effects on protein and energy metabolism and growth hormone status. |
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Ano de publicação: |
1987 |
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Fonte/Imprenta: |
Journal of Endocrinology, v. 115, n. 3, p. 439-446, Dec. 1987. |
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DOI: |
10.1677/joe.0.1150439 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The effects of episodic infusion of testosterone into the vascular system on energy expenditure, nitrogen retention and whole body protein synthesis (determined from [1-14C]leucine kinetics) were studied in castrated male lambs under conditions of controlled food intake. Comparisons were made between a 10-day control period and a 10-day treatment period for each lamb. Infusion of testosterone produced a significant increase in heat production, but the magnitude (198 kJ/day, +2.5%) was less than the differences in energy expenditure expected between entire and castrated male ruminants. The retention of nitrogen improved by 1.24 g/day (+22%) in response to the administration of androgen, and this was accompanied by a decrease in amino acid oxidation. Total protein synthesis also declined, and the anabolic nature of testosterone supply must, therefore, be effected through a reduction in the breakdown of protein, the mechanism being similar to that proposed for certain anabolic steroids and the beta-agonist, clenbuterol. Contrary to other reports, the presence of testosterone had no effect on the plasma concentration of GH. |
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Palavras-Chave: |
Drug effects; Growth Hormone. |
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Thesaurus Nal: |
Biosynthesis; Energy Metabolism; Leucine; Nitrogen; Pharmacokinetics; Pharmacology; Proteins; Sheep; Testosterone. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02017naa a2200313 a 4500
001 2071054
005 2017-06-16
008 1987 bl uuuu u00u1 u #d
024 7 $a10.1677/joe.0.1150439$2DOI
100 1 $aLOBLEY, G. E.
245 $aAdministration of testosterone to wether lambs$beffects on protein and energy metabolism and growth hormone status.
260 $c1987
520 $aAbstract: The effects of episodic infusion of testosterone into the vascular system on energy expenditure, nitrogen retention and whole body protein synthesis (determined from [1-14C]leucine kinetics) were studied in castrated male lambs under conditions of controlled food intake. Comparisons were made between a 10-day control period and a 10-day treatment period for each lamb. Infusion of testosterone produced a significant increase in heat production, but the magnitude (198 kJ/day, +2.5%) was less than the differences in energy expenditure expected between entire and castrated male ruminants. The retention of nitrogen improved by 1.24 g/day (+22%) in response to the administration of androgen, and this was accompanied by a decrease in amino acid oxidation. Total protein synthesis also declined, and the anabolic nature of testosterone supply must, therefore, be effected through a reduction in the breakdown of protein, the mechanism being similar to that proposed for certain anabolic steroids and the beta-agonist, clenbuterol. Contrary to other reports, the presence of testosterone had no effect on the plasma concentration of GH.
650 $aBiosynthesis
650 $aEnergy Metabolism
650 $aLeucine
650 $aNitrogen
650 $aPharmacokinetics
650 $aPharmacology
650 $aProteins
650 $aSheep
650 $aTestosterone
653 $aDrug effects
653 $aGrowth Hormone
700 1 $aCONNELL, A.
700 1 $aBUCHAN, V.
700 1 $aSKENE, P. A.
700 1 $aFLETCHER, J. M.
773 $tJournal of Endocrinology$gv. 115, n. 3, p. 439-446, Dec. 1987.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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